Tramiprosate → HCID 86705362, compound

HRID 1773656Notes

Reaction equation

HRID 1773656 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6].[H-].[Na+].[Br:11][C:12]1[CH:13]=[C:14](S(C)(=O)=O)[C:15]2[N:16]([C:18]([C:21]3[CH:32]=[CH:31][C:24]([C:25]([NH:27][CH:28]4[CH2:30][CH2:29]4)=[O:26])=[C:23]([CH3:33])[CH:22]=3)=[CH:19][N:20]=2)[N:17]=1>CS(C)=O>[Br:11][C:12]1[CH:13]=[C:14]([NH:1][CH2:2][CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6])[C:15]2[N:16]([C:18]([C:21]3[CH:32]=[CH:31][C:24]([C:25](=[O:26])[NH:27][CH:28]4[CH2:30][CH2:29]4)=[C:23]([CH3:33])[CH:22]=3)=[CH:19][N:20]=2)[N:17]=1

Participants

5

Reactant 3

HCID 1646TramiprosateHCID 24758Sodium hydrideHCID 86705361HCID 86705361, compound

Product 1

HCID 86705362HCID 86705362, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a stirred solution of 41 mg (300 μmol) 3-aminopropane-1-sulfonic acid in 2 mL DMSO is added 24 mg (600 μmol) sodium hydride at rt. After 30 min, 90 mg (200 μmol) 4-[6-bromo-8-(methylsulfonyl)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropyl-2-methyl benzamide are added which was prepared according to intermediate example 516b to give after stirring for 2 h, the crude title compound which was used after evaporation of the solvent without further workup.

Workup

  1. customwas prepared
  2. customto give

Sources & evidence

ORD record
ord-b958863d68984cb4a8818309a379da6d
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

Loading…