Hydrogen Bromide → HCID 66691682, compound

HRID 1773657Notes

Reaction equation

HRID 1773657 reaction equation
C1(N[C:5](=[O:37])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]4[N:17]=[C:18]([O:28][C:29]5[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=5)[CH:19]=[C:20]([NH:21][CH2:22][CH2:23][C:24]([F:27])([F:26])[F:25])[C:15]4=[N:14][CH:13]=3)=[CH:8][C:7]=2[CH3:36])CC1.Br.[OH2:39]>>[F:35][C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][CH:32]=1)[O:28][C:18]1[CH:19]=[C:20]([NH:21][CH2:22][CH2:23][C:24]([F:27])([F:25])[F:26])[C:15]2[N:16]([C:12]([C:9]3[CH:10]=[CH:11][C:6]([C:5]([OH:37])=[O:39])=[C:7]([CH3:36])[CH:8]=3)=[CH:13][N:14]=2)[N:17]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 66691294HCID 66691294, compound

Product 1

HCID 66691682HCID 66691682, compoundYield 9%

Procedure

A mixture comprising 50 mg (97 μmol) N-cyclopropyl-4-{6-(3-fluorophenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide and 0.5 mL hydrobromic acid was heated at 120° C. for 10 minutes under microwave irradiation. Water was added, the precipitate filtered off and purified by chromatography to give 30.0 mg (62%) of title compound A and 4.1 mg (9%) of title compound B.

Workup

  1. filtrationthe precipitate filtered off
  2. custompurified by chromatography

Sources & evidence

ORD record
ord-aa731d3d4d6b4657bd4e0c1696d43b1f
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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