Hydrogen Bromide → HCID 66691873, compound

HRID 1773658Notes

Reaction equation

HRID 1773658 reaction equation
[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([O:6][C:7]2[CH:8]=[C:9]([NH:29][CH2:30][CH2:31][C:32]([F:35])([F:34])[F:33])[C:10]3[N:11]([C:13]([C:16]4[CH:27]=[CH:26][C:19]([C:20](NC5CC5)=[O:21])=[C:18]([CH3:28])[CH:17]=4)=[CH:14][N:15]=3)[N:12]=2)=[CH:4][CH:3]=1.Br.[OH2:39]>>[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([O:6][C:7]2[CH:8]=[C:9]([NH:29][CH2:30][CH2:31][C:32]([F:33])([F:35])[F:34])[C:10]3[N:11]([C:13]([C:16]4[CH:27]=[CH:26][C:19]([C:20]([OH:21])=[O:39])=[C:18]([CH3:28])[CH:17]=4)=[CH:14][N:15]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 66691079HCID 66691079, compound

Product 1

HCID 66691873HCID 66691873, compound

Procedure

A mixture comprising 300 mg (566 μmol) 4-{6-(4-chlorophenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropyl-2-methylbenzamide and 13.4 mL hydrobromic acid was heated at 120° C. for 2.5 days. Water was added, the precipitate filtered off to give the crude title compound that was used without further purification.

Workup

  1. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-013c68271ea74a13ba8e121d94c943a9
Source dataset
uspto-grants-2016_02
Patent number
US09255100B2

Reaction notes

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