Cesium carbonate → HCID 86296177, compound

HRID 1773663Notes

Reaction equation

HRID 1773663 reaction equation
[CH3:1][C:2]1[C:6](B2OC(C)(C)C(C)(C)O2)=[C:5]([CH3:16])[O:4][N:3]=1.C([O-])([O-])=O.[Cs+].[Cs+].[CH3:23][C:24]1[C:28]([C:29]2[CH:30]=[C:31](C3C(C)=CC=C4C=3C=CC=N4)[C:32]3[NH:36][C:35](=[O:37])[NH:34][C:33]=3[CH:38]=2)=[C:27]([CH3:50])[O:26][N:25]=1>>[CH3:23][C:24]1[C:28]([C:29]2[C:38]3[NH:36][C:35](=[O:37])[NH:34][C:33]=3[CH:32]=[C:31]([C:6]3[C:2]([CH3:1])=[N:3][O:4][C:5]=3[CH3:16])[CH:30]=2)=[C:27]([CH3:50])[O:26][N:25]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 27586563,5-Dimethylisoxazole-4-boronic acid pinacol esterHCID 86296389HCID 86296389, compound

Product 1

HCID 86296177HCID 86296177, compound

Procedure

4,6-bis(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-2(3H)-one was synthesized using 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole and Cs2CO3 in a similar fashion as 6-(3,5-dimethylisoxazol-4-yl)-4-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-2(3H)-one (Example 2).

Sources & evidence

ORD record
ord-046627fe002a4a69a23fff1c02c6294a
Source dataset
uspto-grants-2016_02
Patent number
US09255089B2

Reaction notes

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