N-bromobutanimide → HCID 117601993, compound

HRID 1773675Notes

Reaction equation

HRID 1773675 reaction equation
[CH:1]1([C:4]2[CH:8]=[C:7]([CH:9]3[CH2:11][CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.C1C(=O)N([Br:19])C(=O)C1>C(Cl)Cl>[Br:19][C:8]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[N:5][O:6][C:7]=1[CH:9]1[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 117601220HCID 117601220, compound

Product 1

HCID 117601993HCID 117601993, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,5-Dicyclopropylisoxazole (70.0 mg, 0.469 mmol) was treated with NBS (167.0 mg, 0.938 mmol, equiv) in CH2Cl2 at room temperature for 12 h. The solvent was removed under a reduced pressure and the residue was directly loaded onto a silica gel column chromatography (hexane EtOAc 87:13) to give 4-bromo-3,5-dicyclopropylisoxazole.

Workup

  1. customThe solvent was removed under a reduced pressure

Sources & evidence

ORD record
ord-c0fa978576e94d89a2bfb7ab4ff99d31
Source dataset
uspto-grants-2016_02
Patent number
US09255089B2

Reaction notes

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