Diethyl Oxalate → HCID 67960206, compound

HRID 1773780Notes

Reaction equation

HRID 1773780 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[O:5][CH2:6][C:7](=O)[CH3:8].C(OCC)(=O)C(OCC)=O.C(OC(=O)C(=O)CC(=O)COC1C=CC=CC=1)C.C(OC(C1NN=C(COC2C=CC=CC=2)C=1)=O)C.C(OC([C:64]1[N:65]([CH2:77][CH:78]([NH:80][C:81](OC(C)(C)C)=O)C)[N:66]=C(COC2C=CC=CC=2)C=1)=O)C.CC1CN2N=C(COC3C=CC=CC=3)C=C2C(=O)N1.CC1CN2N=C(COC3C=CC=CC=3)C=C2CN1>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[O:5][CH2:6][C:7]1[CH:8]=[C:64]2[CH2:81][NH:80][CH2:78][CH2:77][N:65]2[N:66]=1

Participants

8

Reactant 7

HCID 7268Diethyl OxalateHCID 43413424HCID 43413424, compoundHCID 57435086HCID 57435086, compoundHCID 67958408ethyl 1-{2-[(tert-butoxycarbonyl)amino]propyl}-3-(phenoxymethyl)-1H-pyrazole-5-carboxylateHCID 67960066HCID 67960066, compoundHCID 67960219HCID 67960219, compoundHCID 178469067HCID 178469067, compound

Product 1

HCID 67960206HCID 67960206, compound

Procedure

The compound was prepared from 1-(3-fluoro-phenoxy)-propan-2-one and diethyl oxalate using the methods described in the preceding examples 9 (2,4-dioxo-5-phenoxy-pentanoic acid ethyl ester), 10 (5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester), 11 (rac-2-(2-tert-butoxycarbonylamino-propyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester), 12 (rac-6-methyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one), and 13 (rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine).

Sources & evidence

ORD record
ord-7aca1a1620b14a7a9f6ccddf869f2113
Source dataset
uspto-grants-2016_02
Patent number
US09255103B2

Reaction notes

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