反应详情

温度

0 °C

To a solution of 2-phenylethanol (24.4 g, 0.2 mole) in CH2Cl2 (200 mL) is added NEt3 (30.7 mL, 0.22 mole). The reaction mixture is cooled to 0° C. and methanesulfonyl chloride (16.3 mL, 0.21 mole) is added dropwise. The reaction mixture is allowed to reach room temperature and is stirred at room temperature overnight. Solvent is removed under reduced pressure. Water is added and the aqueous phase is extracted three times with Et2O. The organic phase is washed with water, brine, dried over magnesium sulphate, filtered and the solvent is removed under reduced pressure to give methanesulfonic acid phenethyl ester.

1. customto reach room temperature
2. customSolvent is removed under reduced pressure
3. additionWater is added
4. extractionthe aqueous phase is extracted three times with Et2O
5. washThe organic phase is washed with water, brine
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customthe solvent is removed under reduced pressure