(1-Methylazetidin-3-yl)methanol → 2-iodo-4-(1-methylazetidin-3-ylmethoxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

HRID 1773862Notes

Reaction equation

HRID 1773862 reaction equation
[I:1][C:2]1[N:3]=[C:4]([CH:15]=[O:16])[N:5]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=1.[CH3:17][N:18]1[CH2:21][CH:20]([CH2:22]O)[CH2:19]1>>[I:1][C:2]1[N:3]=[C:4]2[N:5]([CH2:7][CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[CH:15]2[O:16][CH2:22][CH:20]2[CH2:21][N:18]([CH3:17])[CH2:19]2)[CH:6]=1

Participants

3

Reactant 2

HCID 22967022(1-Methylazetidin-3-yl)methanolHCID 867039454-Iodo-1-phenethyl-imidazole-2-carbaldehyde

Product 1

HCID 867039492-iodo-4-(1-methylazetidin-3-ylmethoxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

Procedure

Compound 7A is obtained following the procedure already described in example 2A starting from compound 4-iodo-1-phenethyl-imidazole-2-carbaldehyde (example 2B) and (1-methylazetidin-3-yl)-methanol to give 2-iodo-4-(1-methylazetidin-3-ylmethoxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene melting at 100° C.

Sources & evidence

ORD record
ord-4741e9fe9eea497185a83d108b6e0499
Source dataset
uspto-grants-2016_02
Patent number
US09255101B2

Reaction notes

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