HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → 3-[4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulen-2-yl]-acrylic acid tert-butyl ester oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 3-[4-(1-methyl piperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulen-2-yl]-acrylic acid tert-butyl ester | HCID 86703959 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-[4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulen-2-yl]-acrylic acid tert-butyl ester oxalate | HCID 131734714 | — |
Reaction Steps
3-[4-(1-methyl piperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulen-2-yl]-acrylic acid tert-butyl ester is dissolved in acetone (1.7 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford the compound as an oxalate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255101B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-375542cd0d124c88bdfa3367ba819d7b |
| Source note | uspto-grants-2016_02 |