反应详情

To a solution of acetic acid 3-bromo-4-isopropoxy-phenyl ester (1.44 g, 4.98 mmol, 1.00 eq.) in MeOH (20 mL), a solution of KOH (303 mg, 5.39 mmol, 1.08 eq.) in H2O (3 mL) was added. The resulting mixture was stirred at r.t. for 45 min. Water (5 mL) was added and the mixture was acidified with 2N aq. HCl soln. then extracted with DCM (3×). The comb. org. layers were dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a brown oil. The product was used without purification.

1. extractionthen extracted with DCM (3×)
2. dry with materiallayers were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo