Hydrochloric Acid → HCID 68759107, compound

HRID 1773962Notes

Reaction equation

HRID 1773962 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:12]C(=O)C)[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10].[OH-].[K+].Cl>CO.O>[Br:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:10])[CH3:11]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 89648884HCID 89648884, compound

Product 1

HCID 68759107HCID 68759107, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

To a solution of acetic acid 3-bromo-4-isopropoxy-phenyl ester (1.44 g, 4.98 mmol, 1.00 eq.) in MeOH (20 mL), a solution of KOH (303 mg, 5.39 mmol, 1.08 eq.) in H2O (3 mL) was added. The resulting mixture was stirred at r.t. for 45 min. Water (5 mL) was added and the mixture was acidified with 2N aq. HCl soln. then extracted with DCM (3×). The comb. org. layers were dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a brown oil. The product was used without purification.

Workup

  1. extractionthen extracted with DCM (3×)
  2. dry with materiallayers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-aff0317ef770454595ff81af5193afa1
Source dataset
uspto-grants-2016_02
Patent number
US09255090B2

Reaction notes

Loading…