Sodium Hydroxide → Oxybutynin

HRID 1774103Notes

Reaction equation

HRID 1774103 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][C:7]#[C:8][CH2:9][O:10][C:11]([C:13]([OH:26])([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:12])[CH2:4][CH3:5].Cl.[OH-].[Na+]>OCC(CO)O>[CH3:1][CH2:2][N:3]([CH2:6][C:7]#[C:8][CH2:9][O:10][C:11]([C:13]([OH:26])([CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:12])[CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 91505Oxybutynin hydrochloride3×

Product 1

HCID 4634Oxybutynin

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Conditions

Temperature
25 °C

Procedure

The above composition was prepared by mixing the alcohol, oxybutynin chloride and glycerin in a jacketed mixer for about 5 minutes. The KLUCEL® HF was slowly added while continuing to mix. The water and sodium hydroxide solution are added to obtain a pH of about 6. After all ingredients were added, the mixing continued for 1.5 to 3 hours. The temperature of the mixer was maintained between 15-35° C.

Workup

  1. customThe above composition was prepared
  2. additionThe KLUCEL® HF was slowly added
  3. additionto mix
  4. customto obtain a pH of about 6
  5. additionAfter all ingredients were added

Sources & evidence

ORD record
ord-9fce53089f38416cbe4fd4d7abf2350e
Source dataset
uspto-grants-2016_02
Patent number
US09259388B2

Reaction notes

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