Mafenide → HCID 69012110, compound

HRID 1774128Notes

Reaction equation

HRID 1774128 reaction equation
FC(F)(F)CN.[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1.[Br:19][C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[C:25](NCC1C=CC(F)=CC=1)[N:24]=[C:23]2[NH:39][CH2:40][C:41]([F:44])([F:43])[F:42]>>[Br:19][C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[C:25]([NH:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([NH2:18])(=[O:16])=[O:17])=[CH:13][CH:14]=1)[N:24]=[C:23]2[NH:39][CH2:40][C:41]([F:42])([F:44])[F:43]

Participants

4

Reactant 3

HCID 3998MafenideHCID 9773Ethanamine, 2,2,2-trifluoro-HCID 69012762HCID 69012762, compound

Product 1

HCID 69012110HCID 69012110, compound

Procedure

6-Bromo-2-methanesulfonyl-quinazolin-4-yl)-(2,2,2-trifluoro-ethyl)-amine was reacted with 4-Aminomethyl-benzenesulfonamide in a manner analogous to 6-Bromo-N2-(4-fluoro-benzyl)-N4-(2,2,2-trifluoro-ethyl)-quinazoline-2,4-diamine as described in Example 49. The product was characterized as follows: MS (m/z) 490 [M+H]+; HPLC Rt=1.90 minutes (Method B).

Sources & evidence

ORD record
ord-4d4443ed48b84cd080cb348a053c7988
Source dataset
uspto-grants-2016_02
Patent number
US09259426B2

Reaction notes

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