Potassium Carbonate → HCID 178518249, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-Bromo-quinazoline-2,4-diol (1 g, 4.15 mmol), potassium carbonate (11.6 ml, 0.4 M), tetrakis(triphenylphosphine) palladium (550 mg) and 4-fluorophenyl boronic acid (0.716 g, 5.1 mmol) in DME (40 ml) was heated at 170° C. for 10 minutes by microwave. Solvents were concentrated in vacuo and the residue was purified by RP HPLC with a gradient of H2O, 0.1% TFA-acetonitrile, to provide the desired product in 66% yield (760 mg).

Provenance & Evidence