Hydrochloric Acid → HCID 86696665, compound

HRID 1774166Notes

Reaction equation

HRID 1774166 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[CH:9]=2)[CH:5]=[CH:4][N:3]=1.Cl.[OH-:22].[Na+]>>[O:18]1[CH2:19][CH2:20][CH:15]([NH:14][C:10]2[CH:9]=[C:8]([C:6]3[CH:5]=[CH:4][NH:3][C:2](=[O:22])[CH:7]=3)[CH:13]=[CH:12][N:11]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86696664HCID 86696664, compound

Product 1

HCID 86696665HCID 86696665, compoundYield 98%

Conditions

Temperature
95 °C

Procedure

2′-Fluoro-N-(tetrahydro-2H-pyran-4-yl)-4,4′-bipyridin-2-amine (0.64 g, 2.3 mmol) was combined with 1M HCl (25 mL, 25 mmol) and heated to 95° C. for 3 hours. Upon cooling, the mixture was neutralized (pH 7-8) with of 1M NaOH (25 mL). The resulting slurry was cooled to 0° C. and filtered. The solids were washed with water and dried to give 4-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)pyridin-2(1H)-one (0.62 g, 2.3 mmol, 98% yield) as a solid.

Workup

  1. temperatureUpon cooling
  2. temperatureThe resulting slurry was cooled to 0° C.
  3. filtrationfiltered
  4. washThe solids were washed with water
  5. customdried

Sources & evidence

ORD record
ord-b977a483cb944dc294c60442515704f4
Source dataset
uspto-grants-2016_02
Patent number
US09259470B2

Reaction notes

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