Phenylacetic Acid → Ornithine phenylacetate

HRID 1774246Notes

Reaction equation

C(OC1C=CC=CC=1)(=O)C.[C:11]1([CH2:17][C:18]([OH:20])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(O)(=O)C1C=CC=CC=1.[NH2:30][C@H:31]([C:36]([OH:38])=[O:37])[CH2:32][CH2:33][CH2:34][NH2:35]>>[C:11]1([CH2:17][C:18]([OH:20])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[NH2:30][C@H:31]([C:36]([OH:38])=[O:37])[CH2:32][CH2:33][CH2:34][NH2:35]

Participants

Reactant 3

HCID 999Phenylacetic Acid

HCID 31229Phenyl acetate

HCID 66717857HCID 66717857, compound

Product 1

HCID 44247677Ornithine phenylacetate

Procedure

The phenyl acetate salt may optionally be prepared in solution using phenyl acetic acid and an appropriate base. This solution may be intermixed with L-ornithine benzoate to obtain L-ornithine phenyl acetate as described above. As an example, phenyl acetic acid may be intermixed with sodium hydroxide in isopropanol to obtain a solution of sodium phenyl acetate. The solution of sodium phenyl acetate can then be intermixed with a solution of L-ornithine benzoate. Alternatively, the phenyl acetate salt may optionally be isolated as a solid before intermixing with L-ornithine benzoate.

Sources & evidence

ORD record: ord-652a0a68eec045d794659daad9ef5aad
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260379B2

Reaction notes

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