Ammonia → 2-Propenamide, 3-phenyl-
Reaction equation
[C:1]([O:11]C)(=O)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH3:13]>CO>[C:1]([NH2:13])(=[O:11])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
A solution of methyl cinnamate (28 mmol) and 7M ammonia in MeOH (30 ml) was sealed in a 100 ml thick-wall round bottom flashed, and heated at 90° C. with stirring for 72 h, resulting in a brown solution. After the solvent was removed by a rotary evaporator, the crude products were purified by flash silica gel chromatography (eluting with 2-10% MeOH in DCM) to afford cinnamamide.
Workup
- customresulting in a brown solution
- customAfter the solvent was removed by a rotary evaporator
- customthe crude products were purified by flash silica gel chromatography (eluting with 2-10% MeOH in DCM)
Sources & evidence
- ORD record
- ord-f89143d9875445349fdf3b08bb63c741
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260382B2
Reaction notes
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