3-Bromopropionic acid → HCID 178525586, compound

HRID 1774323Notes

Reaction equation

HRID 1774323 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19]>C1COCC1>[Br-:15].[C:18]([CH2:17][CH2:16][N:12]1[CH:13]=[CH:14][N+:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[CH:11]1)([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 115533-Bromopropionic acidHCID 1231551-(4-Nitrophenyl)-1H-imidazole

Product 1

HCID 178525586HCID 178525586, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

According to the general synthesis procedure, 0.756 mmol (0.250 g) 1-(4-nitrophenyl)imidazole and 0.756 mmol (0.115 g) 3-bromopropionic acid are dissolved in 5 ml THF and heated for 17 h to 90° C.

Workup

  1. temperatureheated for 17 h to 90° C.

Sources & evidence

ORD record
ord-e37fe83bf1c64d7499f6eb7c37f7d9d4
Source dataset
uspto-grants-2016_02
Patent number
US09260397B2

Reaction notes

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