HCID 66648453, compound → HCID 59706552, compound

HRID 1774374Notes

Reaction equation

HRID 1774374 reaction equation
[CH2:1]([CH:8]([C:16]([OH:18])=[O:17])[C:9]([CH2:14][CH3:15])(O)[C:10]([OH:12])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OC(=O)C)(=O)C>[CH2:1]([C:8]1[C:16]([O:18][C:10](=[O:12])[C:9]=1[CH2:14][CH3:15])=[O:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 66648453HCID 66648453, compound

Product 1

HCID 59706552HCID 59706552, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
110 °C

Procedure

The 3-Benzyl-2-ethyl-2-hydroxysuccinic acid obtained was dissolved in acetic anhydride (35 mL) and stirred at 110° C. for 15 h. The residue obtained by evaporating the acetic anhydride of the reaction mixture under reduced pressure was subjected to silica gel column chromatography (hexane-toluene-ethyl acetate 8:3:1) to give 619 mg of the title compound as oil (yield: 79%).

Workup

  1. customThe residue obtained
  2. customby evaporating the acetic anhydride of the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-0fbc5a679eb84441b8ab91f19049c195
Source dataset
uspto-grants-2016_02
Patent number
US09260375B2

Reaction notes

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