HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane;tetrahydrofuran → HCID 59699298, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | 2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1h-imidazol-4-yl}-phenoxy)-1-(4-pyridin-4-yl-piperazin-1-yl)-ethanone | HCID 59301113 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59699298 | HCID 59699298 | — |
Reaction Steps
The product of Example 522 was taken in 4 ml of THF to which was added 5 eq. of BH3-THF solution and the reaction was heated to reflux until the reaction was complete. The crude product was purified by silica gel chromatography to afford Example 527.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737285B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-ee3372dc62ea490098f84a18483b91e6 |
| Source note | uspto-grants-2010_06 |