HRID17745

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2723981

未命名化合物

结构：CC(C)Cc1nc(-c2ccc(OCC(=O)N3CCN(c4ccncc4)CC3)cc2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1

HCID59301113

未命名化合物

PRODUCTS

生成物

结构：CC(C)Cc1nc(-c2ccc(OCCN3CCN(c4ccncc4)CC3)cc2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1

HCID59699298

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The product of Example 522 was taken in 4 ml of THF to which was added 5 eq. of BH3-THF solution and the reaction was heated to reflux until the reaction was complete. The crude product was purified by silica gel chromatography to afford Example 527.

WORKUP

后处理

temperaturethe reaction was heated
temperatureto reflux until the reaction
customThe crude product was purified by silica gel chromatography
customto afford Example 527

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ee3372dc62ea490098f84a18483b91e6
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07737285B2
来源说明: uspto-grants-2010_06

反应 SMILES

[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:39]=[CH:38][C:21]([O:22][CH2:23][C:24]([N:26]5[CH2:31][CH2:30][N:29]([C:32]6[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=6)[CH2:28][CH2:27]5)=O)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:40][CH:41]([CH3:43])[CH3:42])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.B.C1COCC1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:39]=[CH:38][C:21]([O:22][CH2:23][CH2:24][N:26]5[CH2:27][CH2:28][N:29]([C:32]6[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=6)[CH2:30][CH2:31]5)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:40][CH:41]([CH3:42])[CH3:43])=[CH:9][CH:8]=2)=[CH:44][CH:45]=1