Borane;tetrahydrofuran → HCID 59699298, compound

HRID 17745Notes

Reaction equation

HRID 17745 reaction equation
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:39]=[CH:38][C:21]([O:22][CH2:23][C:24]([N:26]5[CH2:31][CH2:30][N:29]([C:32]6[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=6)[CH2:28][CH2:27]5)=O)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:40][CH:41]([CH3:43])[CH3:42])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.B.C1COCC1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:39]=[CH:38][C:21]([O:22][CH2:23][CH2:24][N:26]5[CH2:27][CH2:28][N:29]([C:32]6[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=6)[CH2:30][CH2:31]5)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:40][CH:41]([CH3:42])[CH3:43])=[CH:9][CH:8]=2)=[CH:44][CH:45]=1

Participants

4

Reactant 2

HCID 2723981Borane;tetrahydrofuranHCID 593011132-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1h-imidazol-4-yl}-phenoxy)-1-(4-pyridin-4-yl-piperazin-1-yl)-ethanone

Product 1

HCID 59699298HCID 59699298, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 522 was taken in 4 ml of THF to which was added 5 eq. of BH3-THF solution and the reaction was heated to reflux until the reaction was complete. The crude product was purified by silica gel chromatography to afford Example 527.

Workup

  1. temperaturethe reaction was heated
  2. temperatureto reflux until the reaction
  3. customThe crude product was purified by silica gel chromatography
  4. customto afford Example 527

Sources & evidence

ORD record
ord-ee3372dc62ea490098f84a18483b91e6
Source dataset
uspto-grants-2010_06
Patent number
US07737285B2

Reaction notes

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