反应详情

A solution of 2-propylthiophene (1.00 g, 7.92 mmol) and N-bromosuccinimide (1.55 mg, 8.71 mmol) in N,N-Dimethylformamide (60 mL) was heated at 65° C. for 4 hours. The reaction mixture was concentrated in vacuo. The residue was dissolved in cyclohexane (20 mL) and successively washed with a 5% sodium thiosulfate solution (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo to provide 2-bromo-5-propylthiophene (11a) (1.45 g, 7.07 mmol, 89%) which was used without further purification.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in cyclohexane (20 mL)
3. washsuccessively washed with a 5% sodium thiosulfate solution (15 mL) and brine (15 mL)
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated in vacuo