Hydrochloric Acid → HCID 21193865, compound

Participants

Reaction Steps

Into a 250 ml round-bottomed flask 55.0 g (19.1 millimoles) of N-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-phenyl]-glycinate (13, R is methyl) and 100 ml of a 5 vol % sodium hydroxide solution (125 millimoles) are weighed in. The suspension obtained is stirred at room temperature for 16-20 hours. The solution obtained is cooled and the pH is adjusted to 5 with a 1:1 diluted mixture of concentrated hydrochloric acid and water. The precipitate is filtered, washed with water and dried in vacuo to constant weight. Thus 4.30 g of the title compound are obtained (97%). Mp.: 178-181° C.

Provenance & Evidence