Hydrochloric Acid → HCID 21193865, compound

HRID 1774605Notes

Reaction equation

HRID 1774605 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][C:15]([O-:17])=[O:16])=[CH:9][CH:8]=2)[N:3]=1.[OH-].[Na+].Cl>O>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:11][CH:12]=2)[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86720702HCID 86720702, compound

Product 1

HCID 21193865HCID 21193865, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a 250 ml round-bottomed flask 55.0 g (19.1 millimoles) of N-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-phenyl]-glycinate (13, R is methyl) and 100 ml of a 5 vol % sodium hydroxide solution (125 millimoles) are weighed in. The suspension obtained is stirred at room temperature for 16-20 hours. The solution obtained is cooled and the pH is adjusted to 5 with a 1:1 diluted mixture of concentrated hydrochloric acid and water. The precipitate is filtered, washed with water and dried in vacuo to constant weight. Thus 4.30 g of the title compound are obtained (97%). Mp.: 178-181° C.

Workup

  1. customThe suspension obtained
  2. customThe solution obtained
  3. temperatureis cooled
  4. additiondiluted
  5. filtrationThe precipitate is filtered
  6. washwashed with water
  7. customdried in vacuo to constant weight

Sources & evidence

ORD record
ord-2f16534ac69340959d15afe7c25bc8d3
Source dataset
uspto-grants-2016_02
Patent number
US09260421B2

Reaction notes

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