反应详情

温度

90 °C

A suspension of 2,2-dimethyl-N-[5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yl]-propionamide (0.195 g, 0.578 mmol) in 1N aqueous HCl (5.78 mL) was heated to 90° C. over night. The reaction mixture was evaporated to dryness and the resulting solid material was triturated in MeOH, filtered off and further dried in a the high vacuum to give the title compound (0.115 g, 69%) as an off white solid as the HCl salt. MS: 254.1 (M+H+).

1. customThe reaction mixture was evaporated to dryness
2. customthe resulting solid material was triturated in MeOH
3. filtrationfiltered off
4. customfurther dried in a the high vacuum