2-Piperidone → HCID 86679118, compound

HRID 1774739Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].[Br:8][C:9]1[CH:10]=[N:11][CH:12]=[C:13]([CH2:15]Cl)[CH:14]=1.[H-].[Na+]>>[Br:8][C:9]1[CH:14]=[C:13]([CH2:15][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C:2]2=[O:7])[CH:12]=[N:11][CH:10]=1

Participants

Reactant 3

HCID 126652-Piperidone

HCID 24758Sodium hydride

HCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 86679118HCID 86679118, compound

Procedure

In analogy to the procedure described for the preparation of intermediates A-12 [B], piperidin-2-one was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in the presence of NaH to give the title compound as a colorless oil. MS: 269.2, 271.2 (M+H+).

Sources & evidence

ORD record: ord-154fbfe54b2a4b8b80c97ddcaeaf2ad8
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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