Sodium hydride → HCID 86679120, compound

HRID 1774741Notes

Reaction equation

HRID 1774741 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][NH:5]1.[Br:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH2:16]Cl)[CH:15]=1.[H-].[Na+]>>[Br:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH2:16][N:5]2[CH2:6][CH2:7][CH2:8][C@H:4]2[CH2:3][O:2][CH3:1])[CH:15]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidineHCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 86679120HCID 86679120, compound

Procedure

In analogy to the procedure described for the preparation of intermediates A-12 [B], (S)-2-(methoxymethyl)pyrrolidine was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in presence of NaH to give the title compound as a yellow oil. MS: 285.0, 286.9 (M+H+).

Sources & evidence

ORD record
ord-8210ffc043974a7c85fb32dcc448610c
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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