HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-Bromo-5-[(S)-2-(2,2,2-trifluoro-ethoxymethyl)-pyrrolidin-1-ylmethyl]-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-5-(chloromethyl)pyridine | HCID 11701259 | — |
| Reactant | (S)-2-(2,2,2-Trifluoro-ethoxymethyl)-pyrrolidine | HCID 86679128 | — |
| Product | 3-Bromo-5-[(S)-2-(2,2,2-trifluoro-ethoxymethyl)-pyrrolidin-1-ylmethyl]-pyridine | HCID 86679129 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediates A-12 [B], (S)-2-(2,2,2-trifluoro-ethoxymethyl)-pyrrolidine was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in presence of NaH to give the title compound as a yellow oil. MS: 353.1, 355.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-feec67488d17445cb0ef7366d4c3e273 |
| Source note | uspto-grants-2016_02 |