Methyl iodide → HCID 86679130, compound

HRID 1774752Notes

Reaction equation

HRID 1774752 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7](=[O:13])[CH2:6][CH2:5]2.CI.[CH3:16]C(C)([O-])C.[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([CH3:16])[C:7](=[O:13])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 23665647Potassium tert-butoxideHCID 434576896-bromo-7-fluoro-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 86679130HCID 86679130, compound

Procedure

In analogy to the procedure described for the preparation of intermediates A-1 [A], 6-bromo-7-fluoro-3,4-dihydro-1H-quinolin-2-one was reacted with methyl iodide in presence of potassium tert-butoxide to give the title compound as a white foam. MS: 258.0, 259.9 (M+H+).

Sources & evidence

ORD record
ord-549ee427621a4463b9d21615c0191f7a
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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