2,6-Dichloropyrazine → HCID 86679133, compound

HRID 1774753Notes

Reaction equation

HRID 1774753 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:11][C:10]2([CH2:14][NH:13][CH2:12]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:21]=[N:20][CH:19]=[C:18](Cl)[N:17]=1.CCN(C(C)C)C(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:11][C:10]2([CH2:12][N:13]([C:18]3[CH:19]=[N:20][CH:21]=[C:16]([Cl:15])[N:17]=3)[CH2:14]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 785042,6-DichloropyrazineHCID 81531DiisopropylethylamineHCID 401519812-Boc-2,6-diazaspiro(3.3)heptane

Product 1

HCID 86679133HCID 86679133, compound

Procedure

In analogy to the procedure described for the preparation of intermediate A-20, 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester was reacted with 2,6-dichloropyrazine in presence of Hunig's base to give the title compound as a white solid.

Sources & evidence

ORD record
ord-6e98dc13586d4bc38efda26c21f9ebb5
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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