HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (R)-2-Methyl-propane-2-sulfinic acid (5-bromo-4-methyl-pyridin-3-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| Reactant | 5-Bromo-4-methylpyridine-3-carbaldehyde | HCID 22238337 | — |
| Reactant | HCID 178421701 | HCID 178421701 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-2-Methyl-propane-2-sulfinic acid (5-bromo-4-methyl-pyridin-3-ylmethyl)-amide | HCID 86679150 | — |
Reaction Steps
(R)-2-Methyl-propane-2-sulfinic acid 1-(5-bromo-4-methyl-pyridin-3-yl)-meth-(E)-ylideneamide, prepared from (R)-2-methylpropane-2-sulfinamide and 5-bromo-4-methyl-pyridine-3-carbaldehyde in analogy to procedure described for the preparation of intermediate A-35 [A], has been reduced with NaBH4 in MeOH in analogy to the procedure described for the preparation of intermediate A-35 [B] to give the title compound as colorless solid. MS: 305.3 and 307.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-c895099bf914452d8b98634bc38228b5 |
| Source note | uspto-grants-2016_02 |