Propionic Acid → N-{2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-propionamide
Reaction equation
Cl.[NH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]([CH3:22])[C:17](=[O:23])[CH2:16][CH2:15]3)[CH:9]=[N:10][CH:11]=1.[C:24](O)(=[O:27])[CH2:25][CH3:26]>>[CH3:22][N:18]1[C:19]2[C:14](=[CH:13][C:12]([C:8]3[CH:7]=[C:6]([O:5][CH2:4][CH2:3][NH:2][C:24](=[O:27])[CH2:25][CH3:26])[CH:11]=[N:10][CH:9]=3)=[CH:21][CH:20]=2)[CH2:15][CH2:16][C:17]1=[O:23]Participants
3
Procedure
In analogy to the procedure described for the preparation of example 37, 6-[5-(2-amino-ethoxy)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 42) has been reacted with propionic acid to give the title compound as a white solid. MS: 354.3 (M+H+).
Sources & evidence
- ORD record
- ord-d366244ee02e4efd9bfb69334acd755a
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09260408B2
Reaction notes
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