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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1774808Generated: October 31, 2026

Propionic Acid → N-{2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-propionamide

https://huagongshe.com/reaction/1774808

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropionic AcidHCID 1032—
Reactant6-[5-(2-Amino-ethoxy)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochlorideHCID 86679164—
ProductN-{2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-propionamideHCID 71533504—

Reaction Steps

In analogy to the procedure described for the preparation of example 37, 6-[5-(2-amino-ethoxy)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 42) has been reacted with propionic acid to give the title compound as a white solid. MS: 354.3 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09260408B2
Source datasetuspto-grants-2016_02
ORD IDord-d366244ee02e4efd9bfb69334acd755a
Source noteuspto-grants-2016_02