Potassium trimethylsilanolate → HCID 86679168, compound

HRID 1774815Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:14])([CH3:13])[C:9]([O:11]C)=[O:10])[CH:5]=[N:6][CH:7]=1.C[Si](C)(C)[O-].[K+:20]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:14])([CH3:13])[C:9]([O-:11])=[O:10])[CH:5]=[N:6][CH:7]=1.[K+:20]

Participants

Reactant 2

HCID 23668039Potassium trimethylsilanolate

HCID 59619900HCID 59619900, compound

Product 1

HCID 86679168HCID 86679168, compound

Procedure

In analogy to the procedure described for the preparation of example 59 [B], methyl 2-(5-bromopyridin-3-yl)-2-methylpropanoate (example 72 [A]) was reacted with 90% potassium trimethylsilanolate to give the title compound as a light brown solid. MS: 244.3 (M+H+).

Sources & evidence

ORD record: ord-4007e43126304e8aaf282e05f54ca073
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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