HCID 89689581, compound → HCID 66596236, compound

HRID 1774941Notes

Reaction equation

HRID 1774941 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:11])=[N:5][CH:6]=[C:7]([CH:9]=[CH2:10])[N:8]=1>C(O)C.[Pd]>[CH2:9]([C:7]1[N:8]=[C:3]([O:2][CH3:1])[C:4]([NH2:11])=[N:5][CH:6]=1)[CH3:10]

Participants

4

Reactant 1

HCID 89689581HCID 89689581, compound

Product 1

HCID 66596236HCID 66596236, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-methoxy-5-vinylpyrazin-2-amine (490 mg, 3.08 mmol; see step 1) in 50 mL ethanol was hydrogenated under atmospheric hydrogen pressure using an H-cube employed with a Pd/C-cartridge. Complete conversion were observed and the volatile components were removed using a rotary evaporator to deliver 500 mg (95%) of the title compound.

Workup

  1. customthe volatile components were removed
  2. customa rotary evaporator

Sources & evidence

ORD record
ord-0a7ea15c98ec40b9838f37ef6ccb443b
Source dataset
uspto-grants-2016_02
Patent number
US09260435B2

Reaction notes

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