Water → HCID 178419284, compound

HRID 1774954Notes

Reaction equation

HRID 1774954 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.C1C(=O)N([I:18])C(=O)C1.O>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([I:18])=[N:9][NH:8][C:5]2=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 120273N-IodosuccinimideHCID 457897785-Bromo-1H-pyrazolo[3,4-c]pyridine

Product 1

HCID 178419284HCID 178419284, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution containing 5-bromo-1H-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S2O5. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine.

Workup

  1. filtrationthen filtered
  2. washThe solid was washed with water and 5% Na2S2O5
  3. dry with materialThe crude product was dried under high vacuum overnight

Sources & evidence

ORD record
ord-849bcbca85004f7cad2bcf9fa1ac2de1
Source dataset
uspto-grants-2016_02
Patent number
US09260425B2

Reaction notes

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