Water → HCID 178419486, compound

HRID 1774959Notes

Reaction equation

HRID 1774959 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[N:2]1.[Br:10]Br.O.[OH-].[Na+]>C(O)(=O)C>[Br:10][C:3]1[C:4]2[C:5](=[CH:6][N:7]=[CH:8][CH:9]=2)[NH:1][N:2]=1

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 24408BromineHCID 64514411H-Pyrazolo[3,4-c]pyridine

Product 1

HCID 178419486HCID 178419486, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1H-pyrazolo[3,4-c]pyridine (1 g), bromine (1.33 g), and water (40 mL) were stirred for 1 h. Basification with 20% sodium hydroxide solution, and adjustment to pH 7 by addition of acetic acid, yielded 3-Bromo-1H-pyrazolo[3,4-c]pyridine (1.1 g, 67%). ESI MS m/z=275 (M+1)

Sources & evidence

ORD record
ord-c6a2eae1594f49609bd45f846296fe88
Source dataset
uspto-grants-2016_02
Patent number
US09260425B2

Reaction notes

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