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HRID1775105

反应详情

EQUATION

反应方程式

HRID 1775105 的结构方程式

REACTANTS

反应物

2
结构：Clc1ccnc(Cl)n1
HCID77531

2,4-Dichloropyrimidine

C4H2Cl2N2

结构：C[Si](C)(C)CCOCn1n[c]([Sn]([CH3])([CH3])[CH3])c2cc(-c3cccnc3)ncc21
HCID71253848

未命名化合物

PRODUCTS

生成物

1
结构：C[Si](C)(C)CCOCn1nc(-c2ccnc(Cl)n2)c2cc(-c3cccnc3)ncc21
HCID86676701

未命名化合物

收率 50%

PROCEDURE

实验过程

Following the Stille coupling procedure of Example 299, 5-(pyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-3-(trimethylstannyl)-1H-pyrazolo[3,4-c]pyridine and 2,4-dichloropyrimidine were reacted. The product was purified via silica gel chromatography using a gradient of ethyl acetate in heptane to afford 60 mg (50%) of 3-(2-Chloropyrimidin-4-yl)-5-(pyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine. ESI MS m/z 439.2 (M+1).

WORKUP

后处理

  1. customwere reacted
  2. customThe product was purified via silica gel chromatography