huagongshe.com
HRID1775107

反应详情

EQUATION

反应方程式

HRID 1775107 的结构方程式

REACTANTS

反应物

2
结构：Brc1cccc(Br)n1
HCID12274

Pyridine, 2,6-dibromo-

C5H3Br2N

结构：C[Si](C)(C)CCOCn1n[c]([Sn]([CH3])([CH3])[CH3])c2cc(-c3cccnc3)ncc21
HCID71253848

未命名化合物

PRODUCTS

生成物

1
结构：C[Si](C)(C)CCOCn1nc(-c2cccc(Br)n2)c2cc(-c3cccnc3)ncc21
HCID86676702

未命名化合物

收率 67%

PROCEDURE

实验过程

Following the Stille coupling procedure of Example 299, 5-(pyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-3-(trimethylstannyl)-1H-pyrazolo[3,4-c]pyridine and 2,6-dibromopyridine were reacted. The mixture was purified via silica gel chromatography using a gradient of ethyl acetate in heptane to afford 81 mg (67%) of 3-(6-Bromopyridin-2-yl)-5-(pyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine. ESI MS m/z 482.2 (M+1).

WORKUP

后处理

  1. customwere reacted
  2. customThe mixture was purified via silica gel chromatography