HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1775146Generated: October 26, 2026
Nitric Acid → 5-nitro-7H-pyrrolo[2,3-d]pyrimidine
https://huagongshe.com/reaction/1775146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine | HCID 261591 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-nitro-7H-pyrrolo[2,3-d]pyrimidine | HCID 57963148 | — |
Reaction Steps
5-Nitro-7H-pyrrolo[2,3-d]pyrimidine (8) is prepared by adding 7H-pyrrolo[2,3-d]pyrimidine (6) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 5-nitro-7H-pyrrolo[2,3-d]pyrimidine 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09260437B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-605c5fd85d2743878f39e8d35b17e094 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
