反应详情

温度

0 °C

5-Nitro-7H-pyrrolo[2,3-d]pyrimidine (8) is prepared by adding 7H-pyrrolo[2,3-d]pyrimidine (6) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 5-nitro-7H-pyrrolo[2,3-d]pyrimidine 8.

1. custom5-Nitro-7H-pyrrolo[2,3-d]pyrimidine (8) is prepared
2. additionis carefully added
3. filtrationThe solids are collected by filtration
4. customdried