Hydrazine hydrate (1:1) → HCID 136242914, compound

HRID 1775212Notes

Reaction equation

HRID 1775212 reaction equation
[CH3:1][N:2]1[CH2:14][C:13](=O)[C:12]2[C:11]3[C:10]([C:16]([O:18]C)=O)=[CH:9][CH:8]=[CH:7][C:6]=3[NH:5][C:4]=2[CH2:3]1.O.NN.C1C2NC3C=CC=C4C(=O)[NH:37][N:38]=C(C=2C=34)CC1>>[CH3:1][N:2]1[CH2:3][C:4]2[NH:5][C:6]3[CH:7]=[CH:8][CH:9]=[C:10]4[C:16](=[O:18])[NH:37][N:38]=[C:13]([C:12]=2[C:11]=34)[CH2:14]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 89657342HCID 89657342, compoundHCID 136242890HCID 136242890, compound

Product 1

HCID 136242914HCID 136242914, compound

Procedure

Compound 44 was prepared from Methyl 2-methyl-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and hydrazine hydrate according to the procedure similar to that for Compound 1. 1H NMR (DMSO-d6) δ 11.7 (s, 1H), 9.87 (s, 1H), 7.43 (d, 1H, J=8.0 Hz), 7.39 (d, 1H, J=7.6 Hz), 7.14 (dd, 1H, J=8.0, 7.6 Hz), 3.70 (s, 2H), 3.13 (s, 2H), and 2.39 (s, 3H). MS (ESI) m/e [M+1]+ 241.

Sources & evidence

ORD record
ord-3044bfb1a2d74062963a53788b8fc41b
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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