Hydrazine hydrate (1:1) → HCID 136242917, compound

HRID 1775215Notes

Reaction equation

HRID 1775215 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:18][C:17](=O)[C:16]3[C:15]4[C:14]([C:20]([O:22]C)=O)=[CH:13][CH:12]=[CH:11][C:10]=4[NH:9][C:8]=3[CH2:7]2)=[O:5])[CH2:3][CH2:2]1.O.NN.C1C2NC3C=CC=C4C(=O)[NH:41][N:42]=C(C=2C=34)CC1>>[CH:1]1([C:4]([N:6]2[CH2:7][C:8]3[NH:9][C:10]4[CH:11]=[CH:12][CH:13]=[C:14]5[C:20](=[O:22])[NH:41][N:42]=[C:17]([C:16]=3[C:15]=45)[CH2:18]2)=[O:5])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 89657224HCID 89657224, compoundHCID 136242890HCID 136242890, compound

Product 1

HCID 136242917HCID 136242917, compound

Procedure

Compound 47 was prepared from methyl 2-(cyclopropanecarbonyl)-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and hydrazine hydrate according to the the procedure similar to that for Compound 1. 1H NMR (DMSO-d6) δ 11.9 (s, 1H), 10.0 (s, 1H), 7.47-7.53 (m, 2H), 7.17 (dd, 1H, J=7.2, 7.8 Hz), 4.89 (s, 2H), 4.35 (s, 2H), 2.08-2.11 (m, 1H), and 0.78-0.79 (m, 4H). MS (ESI) m/e [M+1]+ 295.

Sources & evidence

ORD record
ord-587702226faa411ea900bc873f6aaa9d
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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