Cyclopropanecarbonyl chloride → HCID 136242918, compound

HRID 1775217Notes

Reaction equation

HRID 1775217 reaction equation
[F:1]C1C=C(C(OC)=O)C2C3C(=O)CNCC=3NC=2C=1.C1(C(Cl)=O)CC1.[CH:26]1([C:29]([N:31]2[CH2:43][C:42]3[NH:41][C:40]4[CH:39]=[CH:38][CH:37]=[C:36]5[C:44](=[O:47])[NH:45][N:46]=[C:33]([C:34]=3[C:35]=45)[CH2:32]2)=[O:30])[CH2:28][CH2:27]1>>[CH:26]1([C:29]([N:31]2[CH2:43][C:42]3[NH:41][C:40]4[CH:39]=[C:38]([F:1])[CH:37]=[C:36]5[C:44](=[O:47])[NH:45][N:46]=[C:33]([C:34]=3[C:35]=45)[CH2:32]2)=[O:30])[CH2:27][CH2:28]1

Participants

4

Reactant 3

HCID 77637Cyclopropanecarbonyl chlorideHCID 89657628HCID 89657628, compoundHCID 136242917HCID 136242917, compound

Product 1

HCID 136242918HCID 136242918, compound

Procedure

Compound 49 was prepared from methyl 7-fluoro-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and cyclopropanecarbonyl chloride according to the procedures similar to those for Compound 47. 1H NMR (DMSO-d6) δ 9.64 (s, 1H), 6.80-7.08 (m, 2H), 4.95 (s, 1H), 4.74 (s, 1H), 4.40 (s, 1H), 4.20 (s, 1H), 2.03-2.07 (m, 1H), and 0.75 (s, 4H). MS (ESI) m/e [M+1]+ 313.

Sources & evidence

ORD record
ord-2fd21e51a5e04c0e95c731ad20230948
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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