Hydrazine hydrate (1:1) → HCID 136242928, compound

HRID 1775228Notes

Reaction equation

HRID 1775228 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][N:5]1[CH2:17][C:16](=O)[C:15]2[C:14]3[C:13]([C:19]([O:21]C)=O)=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7]=2[CH2:6]1.O.NN.C1C2NC3C=CC=C4C(=O)[NH:41][N:42]=C(C=2C=34)CC1>>[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][N:5]1[CH2:6][C:7]2[NH:8][C:9]3[CH:10]=[CH:11][CH:12]=[C:13]4[C:19](=[O:21])[NH:41][N:42]=[C:16]([C:15]=2[C:14]=34)[CH2:17]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 89657341HCID 89657341, compoundHCID 136242890HCID 136242890, compound

Product 1

HCID 136242928HCID 136242928, compound

Procedure

Compound 60 was prepared from methyl 2-(2-(dimethylamino)ethyl)-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and hydrazine hydrate according to the procedure similar to that for Compound 1. 1H NMR δ 9.92 (s, 1H), 7.60 (d, 1H, J=8.4 Hz), 7.46 (d, 1H, J=7.8 Hz), 7.13 (dd, 1H, J=8.4, 7.8 Hz), 4.20-4.22 (m, 2H), 4.03 (s, 2H), 3.41 (s, 2H), 2.51-2.54 (m, 2H), and 2.18 (s, 6H). MS (ESI) m/e [M+1]+ 298.

Sources & evidence

ORD record
ord-c0afba0ab4914b149f224b5c2866190d
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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