Hydrazine hydrate (1:1) → HCID 136952096, compound

HRID 1775231Notes

Reaction equation

HRID 1775231 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:33])([CH3:32])[C:13]([N:15]1[CH2:27][C:26](=O)[C:25]2[C:24]3[C:23]([C:29]([O-])=[O:30])=[CH:22][CH:21]=[CH:20][C:19]=3[NH:18][C:17]=2[CH2:16]1)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN.C1C2NC3C=CC=C4C(=O)[NH:51][N:52]=C(C=2C=34)CC1>>[CH2:1]([O:8][C:9](=[O:10])[NH:11][C:12]([CH3:33])([CH3:32])[C:13](=[O:14])[N:15]1[CH2:16][C:17]2[NH:18][C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[C:29](=[O:30])[NH:51][N:52]=[C:26]([C:25]=2[C:24]=34)[CH2:27]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 131734731HCID 131734731, compoundHCID 136242890HCID 136242890, compound

Product 1

HCID 136952096HCID 136952096, compound

Procedure

The target product was prepared from 2-(2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-4-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-5-carboxylate and hydrazine hydrate according to the procedure similar to that for Compound 1. 1H NMR (DMSO-d6) δ 11.8 (s, 1H), 10.2 (s, 1H), 7.18-7.55 (m, 8H), 4.82-4.91 (m, 4H), 4.43-4.55 (m, 2H), 1.25 (s, 6H). MS (ESI) m/e [M+1]+ 446.

Sources & evidence

ORD record
ord-997617f7fcfd4194a24856d63d47d01b
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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