Hydrochloric Acid → HCID 136242932, compound

HRID 1775234Notes

Reaction equation

HRID 1775234 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:9](=[O:27])[N:10]1[CH2:22][C:21]2[NH:20][C:19]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:23](=[O:26])[NH:24][N:25]=[C:12]([C:13]=2[C:14]=34)[CH2:11]1)(C)(C)C.Cl.NC(C)(C)C(N1CC2NC3C=CC=C4C(=O)NN=C(C=2C=34)C1)=O>>[NH2:7][C@@H:8]([CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:9]([N:10]1[CH2:22][C:21]2[NH:20][C:19]3[CH:18]=[CH:17][CH:16]=[C:15]4[C:23](=[O:26])[NH:24][N:25]=[C:12]([C:13]=2[C:14]=34)[CH2:11]1)=[O:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 136242930HCID 136242930, compoundHCID 136242931HCID 136242931, compound

Product 1

HCID 136242932HCID 136242932, compound

Procedure

Compound 64 was prepared from Compound 63 with hydrogen chloride according to the procedure similar to that for Compound 62. 1H NMR (DMSO-d6) δ 11.9 (s, 1H), 10.1 (s, 1H), 7.48 (d, 1H, J=8.0 Hz), 7.48-7.52 (m, 2H), 7.10-7.20 (m, 6H), 4.93-4.96 (m, 3H), 4.18-4.25 (m, 2H), 4.00-4.03 (m, 2H), 2.78-2.85 (m, 1H), and 2.61-2.65 (m, 1H). MS (ESI) m/e [M+1]+ 374.

Sources & evidence

ORD record
ord-ded7b7716a204f10bcf20a46a45c6b4f
Source dataset
uspto-grants-2016_02
Patent number
US09260440B2

Reaction notes

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