HCID 118034959, compound → 1206978-90-6

HRID 1775296Notes

Reaction equation

HRID 1775296 reaction equation
Br.[Br:2][C:3]1[CH:8]=[CH:7][N:6]2[CH2:9][C:10]([C:13]([F:16])([F:15])[F:14])(O)[N:11]=[C:5]2[CH:4]=1>C(O)C>[Br:2][C:3]1[CH:8]=[CH:7][N:6]2[CH:9]=[C:10]([C:13]([F:15])([F:16])[F:14])[N:11]=[C:5]2[CH:4]=1

Participants

3

Reactant 1

HCID 118034959HCID 118034959, compound

Product 1

HCID 682947471206978-90-6Yield 100.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.82 g of 7-bromo-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide and 10 ml of ethanol was stirred under heat-reflux for 1 day. The cooled reaction mixture was concentrated under reduced pressure, then water was added, and the mixture was extracted with ethyl acetate. The mixture was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 1.33 g of 7-bromo-2-trifluoromethylimidazo[1,2-a]pyridine.

Workup

  1. temperatureunder heat-reflux for 1 day
  2. customThe cooled reaction mixture
  3. concentrationwas concentrated under reduced pressure
  4. additionwater was added
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe mixture was dried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-98065be5b3884d4b8ad934316287c4f4
Source dataset
uspto-grants-2016_02
Patent number
US09260436B2

Reaction notes

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