反应详情

To tert-butyl 4-(3-isoquinolyl)piperazine-1-carboxylate (201 mg, 0.64 mmol) was added a 1:1 mixture of DCM and trifluoroacetic acid, the resulting mixture was stirred at room temperature for one hour. The volatiles were removed under reduced pressure, the residue was dissolved in THF and evaporated again. The residue was dissolved in THF and 4N HCl in 1,4-dioxane was added to precipitate the hydrochloride salt which was collected by filtration and dried under reduced pressure. 123 mg of a solid were obtained (0.49 mmol, 77%). MS (APCI) m/z=214.1 [M+1]+.

1. customThe volatiles were removed under reduced pressure
2. dissolutionthe residue was dissolved in THF
3. customevaporated again
4. dissolutionThe residue was dissolved in THF
5. addition4N HCl in 1,4-dioxane was added
6. customto precipitate the hydrochloride salt which
7. filtrationwas collected by filtration
8. customdried under reduced pressure