Hydrochloric Acid → HCID 118071535, compound

HRID 1775443Notes

Reaction equation

HRID 1775443 reaction equation
[Br:1][C:2]1[C:10]([NH:11]C(=O)OC(C)(C)C)=[CH:9][C:5]2[CH2:6][CH2:7][O:8][C:4]=2[CH:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[Br:1][C:2]1[C:10]([NH2:11])=[CH:9][C:5]2[CH2:6][CH2:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118074739HCID 118074739, compound

Product 1

HCID 118071535HCID 118071535, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a mixture of tert-butyl (6-bromo-2,3-dihydro-1-benzofuran-5-yl)carbamate (2.75 g) and dioxane (15.0 mL) was added hydrogen chloride (4 M dioxane solution, 15.0 mL), followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure to obtain 6-bromo-2,3-dihydro-1-benzofuran-5-amine hydrochloride (2.23 g) as a pale yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-321897fac0f747f989ce1832ce4e3506
Source dataset
uspto-grants-2016_02
Patent number
US09260445B2

Reaction notes

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