3-Iodobenzaldehyde → HCID 66576644, compound

HRID 1775540Notes

Reaction equation

HRID 1775540 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3C)[C:3]=12.[I:25]C1C=C(C=CC=1)C=O>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH3:24])[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([I:25])[CH:18]=3)[C:3]=12

Participants

3

Reactant 2

HCID 2526103-IodobenzaldehydeHCID 66576809HCID 66576809, compound

Product 1

HCID 66576644HCID 66576644, compound

Procedure

Compound 3 was synthesised following similar procedures outlined in Example 25 (Compound 20), using 3-iodobenzaldehyde instead of 2-methylbenzaldehyde in Step 1. As a slightly modified procedure, the crude residue of Step 3 was purified by column chromatography (silica gel, gradient 80 to 100% CH2Cl2/isohexane to 2% diethyl ether/CH2Cl2), yielding Compound 3 as a solid.

Workup

  1. customCompound 3 was synthesised
  2. customAs a slightly modified procedure, the crude residue of Step 3 was purified by column chromatography (silica gel, gradient 80 to 100% CH2Cl2/isohexane to 2% diethyl ether/CH2Cl2)

Sources & evidence

ORD record
ord-33038571ffe444f69addacdad927ee9e
Source dataset
uspto-grants-2016_02
Patent number
US09260381B2

Reaction notes

Loading…